Journal article · Electrochimica Acta 2015
Optimal Dose-Response Relationship in Electrolytic Ablation of Tumors with a One-Probe-Two-Electrode Device
Electrochimica Acta, vol. 186, pp. 494–503, Pergamon, 2015
Abstract
Electrolytic ablation (EA) of tumors consists in the passage of a low constant electric current through two or more electrodes inserted in the tissue thus inducing pH fronts that produce tumor necrosis. Combined with a recently introduced one-probe two electrode device (OPTED) this procedure results in a minimally invasive treatment. In this work, a theoretical model is introduced describing the EA/OPTED as an electrolytic process and the underlying electrochemical reactions through the Nernst-Planck equations for ion transport.
Model results show that the coulomb dosage is a reliable dose parameter and predicts an optimal dose-response relationship for a given tumor size subjected to an EA/OPTED, considering the optimum as the minimum coulomb dosage necessary to achieve total tumor destruction while minimizing healthy tissue damage. Moreover, it predicts a nonlinear relationship between coulomb dosage and necrotized tumor volume, dosage and NTV scaling as Q¹⋅⁴.
The version of record is at doi:10.1016/j.electacta.2015.10.147.
Cite this paper
Download .bib ↓Emmanuel Lujan, Herman Schinca, Nahuel Olaiz, Santiago Urquiza, Fernando Víctor Molina, Pablo Turjanski and Guillermo Marshall, “Optimal Dose-Response Relationship in Electrolytic Ablation of Tumors with a One-Probe-Two-Electrode Device,” Electrochimica Acta, vol. 186, pp. 494–503, Pergamon, 2015.
doi:10.1016/j.electacta.2015.10.147
@article{lujan2015optimal,
title={Optimal Dose-Response Relationship in Electrolytic Ablation of Tumors with a One-Probe-Two-Electrode Device},
author={Luj{\'{a}}n, Emmanuel and Schinca, Herman and Olaiz, Nahuel and Urquiza, Santiago and Molina, Fernando V{\'{i}}ctor and Turjanski, Pablo and Marshall, Guillermo},
journal={Electrochimica Acta},
volume={186},
pages={494--503},
year={2015},
publisher={Pergamon},
doi={10.1016/j.electacta.2015.10.147}
}